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Cody Coyne is a professor of Molecular Pharmacology and Immunology in the Department of Basic Sciences within the College of Veterinary Medicine where he has established a research program devoted to the molecular design, synthesis and potency evaluation of pharmaceuticals. Current research investigations have been devoted to the design of molecular structure, organic chemistry reactions and multi-phase synthesis regimens for covalent immunopharmaceuticals with properties of selective "targeted" delivery and potent anti-neoplastic cytotoxicity. A native of Colorado, Coyne earned a DVM from Colorado State University in Fort Collins; completed a surgery internship, an internal medicine residency, and a PhD graduate degree (radiobiopharmacology design) at the University of California at Davis/Sacramento Medical Center, and attained board certification with diplomate status in the College of Veterinary Internal Medicine while at Kansas State University.
Since arriving at Mississippi State University in 1993, Coyne has received extramural funding from federal, research foundation, and pharmaceutical industry sources primarily for pharmacology-oriented research related to infectious and neoplastic disease states relevant to both man and domestic animal species. In 2000 a U.S. Patent was issued for research methods developed that optimize the isolation, growth and propagation of a unique cell population that has utility for the synthetic production of medicinal glycoproteins through the application of genetic cloning techniques, and as a biological reagent in the development of new vaccine preparations (represents the first CVM research patent). Since that time, numerous pharmacology intellectual properties have been conceived and are in the active stages of development which have lead to the filing of multiple invention disclosures and non-disclosure agreements arranged with domestic pharmaceutical companies. Research that is currently active has generated investigations devoted to the molecular design, organic chemical synthesis and potency evaluation of anti-cancer agents with properties of selective "targeted" delivery that have efficacy against chemotherapeutic-resistant human carcinomas. Parallel research investigations involve the molecular design and chemical synthesis of candidate chemotherapeutics that have been approved for Phase II analysis by a major pharmaceutical company. Chemotherapy and oncology scientific journals are the primary venues where results from these research investigations are published and they represent a majority of the 47 manuscripts published to date. In 2012 he accepted the role of editor for the Pharmaceutical Active Ingredients Special Issue of the journal, Molecules. In 2006 Coyne completed the composition of a book entitled "Comparative Diagnostic Pharmacology: Research and Clinical Applications in Living Systems Models" (85% human/15% animal) which was the first comprehensive text ever published on the subject of diagnostic pharmacology.
Coyne's wife, Joan Cadillac is board certified in laboratory animal medicine and one of four campus veterinarians in the School of Medicine at the University of Alabama in Birmingham.


Comparative Diagnostic Pharmacology: Research and Clinical Applications in Living-Systems Models

Coyne, Cody
Publisher: Blackwell Pub. Professional
2006
ISBN: 0813817536

The text comprehensively describes diagnostic pharmaceuticals and their utilization for the characterization of physiological process and the detection of specific disease conditions. Diagnostic pharmaceuticals are organized according to body systems and the specific disease state or physiological process of interest instead of by alphabetical order of the agent.




Pincus, S. H., K. Song, G. A. Maresh, A. Frank, D. Worthylake, H. K. Chung, P. Polacino, D. H. Hamer, Cody P. Coyne, M. G. Rosenblum, J. W. Marks, G. Chen, D. Weiss, V. Ghetie, E. S. Vitetta, J. E. Robinson, and S. L. Hu. "Design and In-Vivo Characterization of Immunoconjugates Targeting HIV gp160" Journal of Virology 91.3 (2017): e01360-16.
Coyne, Cody and Lakshmi Narayanan. "Dexamethasone-(C21-phosphoramide)-[anti-EGFR]: Molecular Design, Synthetic Organic Chemistry Reactions and Anti-Neoplastic Cytotoxic Potency Against Pulmonary Adenocarcinoma (A549)" Journal of Drug Design, Development and Therapy 10 (2016): 2575-2597.
Coyne, Cody and Lakshmi Narayanan. "Gemcitabine-(5'-phosphoramidate)-[anti-IGF-1R]: Molecular Design, Synthetic Organic Chemistry Reactions, and Antineoplastic Cytotoxic Potency in Populations of Pulmonary Adenocarcinoma (A549)" Chemical Biology and Drug Design (2016): DOI: 10.1111/cbdd.12845.
Coyne, Cody and L. Narayanan. "Fludarabine-(C2-methylhydroxyphosphoramide)-[anti-IGF-1R]: Synthesis and Selectively “Targeted” Anti-Neoplastic Cytotoxicity Against Pulmonary Adenocarcinoma (A549)" Journal of Pharmaceutics and Drug Delivery Research 4.1 (2015): 129.
Coyne, Cody, Toni Jones, and Ryan Bear. "Simultaneous Dual Selective Targeted Delivery of Two Covalent Gemcitabine Immunochemotherapeutics and Complementary Anti-Neoplastic Potency of [Se]-Methylselenocysteine" Journal of Cancer Therapy 6.1 (2015): 62-89.
Coyne, Cody and L. Narayanan. "Fludarabine-(C2-Methylhydroxyphosphoramide)-[anti-IGF-1R]: Synthesis and Selectivity " Journal of Pharmaceutics and Drug Delivery Research (2014):
Coyne, Cody, T. Jones, and R. Bear. "Anti-neoplastic Cytotoxicity of Gemcitabine-(C4-amide)-[anti-EGFR] in Dual Combination with Epirubicin-(C3-amide)-[anti-HER2/neu] against Chemotherapeutic-Resistant Mammary Adenocarcinoma (SKBr-3) and the Complementary Effect of Mebendazole" Journal of Cancer Research Therapeutic Oncology 2.1 (2014): 1-23.
Coyne, Cody, T. Jones, and R. Bear. "Anti-Neoplastic Cytotoxicity of Gemcitabine-(C4-amide)-[anti-HER2/neu] in Combination with Griseofulvin Against Chemotherapeutic-Resistant Mammary Adenocarcinoma (SKBr-3)" Medicinal Chemistry Journal 3.2 (2013): 210-223.
Coyne, Cody, T. Jones, and R. Bear. "Gemcitabine-(C4-amide)-[anti-HER2/neu] Anti-Neoplastic Cytotoxicity in Dual Combination with Mebendazole Against Chemotherapeutic-Resistant Mammary Adenocarcinoma" Journal of Clinical and Experimental Oncology 2.2 (2013): 1-13.
Coyne, Cody P., Toni Jones, and Ryan Bear. "Synthesis of a covalent epirubicin-(C3-amide)-anti-HER2/neu immunochemotherapeutic utilizing a UV-photoactivated anthracycline intermediate" Cancer Biotherapy and Radiopharmaceuticals 27.1 (2012): 41-55.
Coyne, Cody P., Toni Jones, and Ryan Bear. "Synthesis of gemcitabine-(C4-amide)-[anti-HER2/neu] utilizing a UV-photoactivated gemcitabine intermediate: cytotoxic anti-Neoplastic activity against chemotherapeutic-resistant mammary adenocarcinoma SKBr-3" Journal of Cancer Therapy 3.5 (2012): 689-711.
Coyne, Cody P., Toni Jones, and Ryan Bear. "Influence of alternative tubulin inhibitors on the potency of epirubicin-SS-anti-HER2/neu synthesized with a UV-activated intermediate. " Journal of Cancer and Clinical Oncology 1.2 (2012): 49-80.
Coyne, Cody P., Toni Jones, Andrzej Sygula, John Bailey, and Lesya Pinchuk. "Epirubicin-[anti-HER2/neu] synthesized with an epirubicin-(C13-keto) EMCS intermediate: anti-neoplastic activity against chemotherapeutic-resistant SKBr-3 mammary adenocarcinoma in combination with organic selenium" Journal of Cancer Therapy 2.1 (2011): 22-39.
Coyne, Cody P., Toni Jones, and Todd Pharr. "Synthesis of a covalent gemcitabine-(carbamate)-[anti-HER2/neu] immunochemotherapeutic and cytotoxic anti-neoplastic activity against chemotherapeutic-resistant SKBr-3 mammary adenocarcinoma" Bioorganic and Medicinal Chemistry 19 (2011): 67-76.
Hodder, A. D. J., Cody P. Coyne, and J. E. Madigan. "Birth of Live Triplets in a Mare: Case Report" Equine Veterinary Journal 42.1 (2010): 84-85.
Coyne, Cody P., Matt K. Ross, and John G. Bailey. "Dual potency anti-HER2/neu and anti-EGFR anthracycline immunoconjugates in chemotherapeutic-resistant mammary adenocarcinoma combined with cyclosporin A and verapamil P-glycoprotein inhibition. " Journal of Drug Targeting 17.6 (2009): 474-489.
Coyne, Cody P., Ann Rashmir-Raven, Toni Jones, Cathleen Mochal, Robert Linford, Michael Brashier, and Allison Eddy.. "Delineation of Pulmonary Airway Fluid Protein Fractions with HRPO Binding-Avidity by Far-Western Ligand Blot and Mass Spectrometry Analyses: A Model Methodology for Detecting Mannose-Binding Protein Expression Profiles" ACTA BioMedica 2009.80 (2009): 243-261.
Coyne, Cody P. and Joan Cadillac. "Factors Associated with Amounts of Research Funding Obtained from the National Institutes of Health by Colleges and Schools of Veterinary Medicine." American Journal of Veterinary Research 69.12 (2008): 1676-1685.
Coyne, Cody P., Trey Howell, John Baravik, Erica Baravik, Brad Fenwick, and Carla Willetto. "Biochemical entities that influence membrane-associated TNF RII (80-kDa) and IL-1 RI (80-kDa) complex expression and receptor fragment production in adherent vascular endothelium" Pathophysiology 9 (2003): 115.
Coyne, Cody P., Trey Howell, Hrvoje Smodlaka, Carla Willetto, Brad Fenwick, and Earl Chenney. "Biochemical mechanisms that promote variable expression and generate soluble fragments of membrane-associated CD14 complexes in adherent macrophages" Journal of Endotoxin Research 8 (2002): 273-283.
Coyne, Cody P., J. Baravik, T. Howell, E. Baravik, B.W. Fenwick, and C. Willetto. "Biochemical mechanisms that interact with membrane-associated IL-1 RII (60-kDa decoy) receptors in populations of adherent macrophages and vascular endothelium" Cellular Signaling 12 (2001): 765-776..
Coyne, Cody P. and David Brake. "Characterization of Haemonchus contortus-derived cell populations propagated in-vitro in a tissue culture environment and their potential to induce protective immunity in sheep" International Journal of Parasitology 31 (2001): 359-376.
Coyne, Cody P., John Baravik, Erica Baravik, Trey Howell, Brad Fenwick, and Carla Willetto . "Biochemical alteration of membrane-associated IL-6 RI (80-kDa) shedding in populations of adherent macrophages and vascular endothelium" Molecular Immunology 38 (2001): 347-357.
Coyne, Cody P., Carla Willetto, and Brad Fenwich. "A mechanism of TNFR Type II (75-kDa) "shedding" in macrophages" Shock 1 (1999): 19-30.
Pond, Amber L., Howard W.Chambers, Cody P. Coyne,and Janice E. Chambers. "Purification of Two Rat Hepatic Proteins with A-Esterase Activity Toward Chlorpyrifos-Oxon and Paraoxon" American Society for Pharmacology and Experimental Therapeutics 286.3 (1998): 1401-1411.
Coyne, Cody P., Brad Fenwich, and Jerald Ainsworth. "Cytotoxic activity of doxorubicin "loaded" neutrophils against human mammary carcinoma (HTB-19)" Biotherapy 10 (1997): 145-159.
Pond, Amber L., Cody P. Coyne, Howard W. Chambers, and Janice E. Chambers. "Identification and isolation of two rat serum proteins with A-esterase activity towards paraoxon and chlorpyrifos-oxon. " Biochemical Pharmacology 52 (1996): 363-369.
Coyne, Cody P., John T. Moritz, and Brad W. Fenwick. "Inhibition of lipopolysaccharide-induced TNF-alpha production by semisynthetic polymyxin-B conjugated dextran." Biotechnology Therapeutics 5.3-4 (1995): 137-162.
Coyne, Cody P. John Moritz. "Semi-synthesis of polymyxin-B conjugated ovalbumin: evaluation of lipopolysaccharide binding-avidity and neutralization of induced TNF-alpha synthesis" Biotherapy 8 (1995): 69-83.

Liu, Dongyou Stephen Pruett, Cody P. Coyne. "Chapter 37: Alternaria." Molecular Detection of Foodborne Pathogens. Dongyou Liu. United States: CRC Press, 2009. 521-528.
Coyne, Cody P. "Neurology (Equine)." VetStream Equis. VetStream. Bartlow Cambridge United Kingdom: Three Hills Farm, 2003.
Coyne, Cody P. Oehme. "Naturally Occurring Toxins (Chapter 50)." Large Animal Internal Medicine: Second. Brad Smith. St. Louis, MO: Mosby, 1990. 1646-1668.